Welcome to Spatom!
Spatom is a state-of-the-art software to predict protein-protein interaction sites(PPIS). Users can use Spatom webserver to predict protein-protein interaction sites using resolved protein structures or predicted protein structures generated by AlphaFold2 (Github page and online ColabFold ) .
Source code of our server is provided on our Github page https://github.com/Wu-Haonan/Spatom
In Spatom, our task is to predict protein-protein interaction sites based on the protein structure. We first define a weighted digraph for a protein structure to precisely characterize the spatial contacts of residues, then performs a 7-layer weighted digraph convolution, and finally add an improved graph attention layer to drive the predicted sites to form a continuous region.
Spatom was tested on a diverse set of challenging protein–protein complexes and multiple popular disease-related proteins demonstrating great superiority over all the compared methods.
If you think Spatom is useful, please kindly cite the following paper:
Webserver update:
April, 9th, 2022: the first version of Spatom server was established.